Single-Cell Transcriptomic Atlas of the Human Endometrium During the Menstrual Cycle

作者：Wanxin Wang, Felipe Vilella, Pilar Alamá, Inmaculada Moreno, Marco Mignardi, Alina Isakova, Wenying Pan, Carlos Simón, Stephen R. Quake · 发表于：Obstetrical & Gynecological Survey · 年份：2022 · DOI：10.1097/ogx.0000000000001009 · 被引用次数：22 · 研究领域：Reproductive System and Pregnancy

(Abstracted from Nat Med 2020;26:1644–1653) The monthly remodeling, shedding, and regeneration of the endometrium defining the human menstrual cycle is driven by gene expression changes in the underlying tissue hierarchy. Significant heterogeneity exists among cell types in the endometrium, such that multiple cell types vary dramatically in state through a monthly cycle and undergo various forms of differentiation at rapid rates.