Pan-Cancer Analyses Confirmed the Ferroptosis-Related Gene SLC7A11 as a Prognostic Biomarker for Cancer

作者：Yi Lin, Yubing Dong, Wanyu Liu, Xingyun Fan, Ying Sun · 发表于：DOAJ (DOAJ: Directory of Open Access Journals) · 年份：2022 · 被引用次数：29 · 研究领域：Ferroptosis and cancer prognosis、Epigenetics and DNA Methylation、Cancer, Lipids, and Metabolism

Yi Lin,1 Yubing Dong,2 Wanyu Liu,2 Xingyun Fan,2 Ying Sun3 1Department of Anesthesiology, First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning Province, 116011, People’s Republic of China; 2Department of Internal Medicine, First affiliated Hospital of Dalian Medical University, Dalian, Liaoning Province, 116011, People’s Republic of China; 3Department of Digestive Endoscopy, First Affiliated Hospital of Dalian Medical University., Dalian, 116011, Liaoning Province, People’s Republic of ChinaCorrespondence: Ying Sun, Email sunying@firsthosp-dmu.comPurpose: Ferroptosis is an iron-dependent and reactive oxygen species (ROS)-reliant form of cell death, exhibiting cellular, molecular, and gene-level characteristics distinct from those of necrosis, autophagy, apoptosis, and pyroptosis. Solute carrier family 7 member 11 (SLC7A11), which encodes a cystine/glutamate antiporter transmembrane protein, inhibits ferroptosis by importing cystine and promoting glutathione (GSH) biosynthesis and was found to be overexpressed in multiple human cancers. However, the specific role and underlying mechanism of SLC7A11 in cancers remains poorly characterized. This research aimed to identify the relationship between SLC7A11 expression and tumor microenvironment and visualize its prognostic value in pan-cancer.Patients and Methods: Transcriptomic data for 6313 tumors and normal samples across 20 cancer types were acquired from The Cancer Genome Atlas (TCGA) database. Beside...