Matrine Exerts Pharmacological Effects Through Multiple Signaling Pathways: A Comprehensive Review

作者：Yingda Lin, Fuming He, Ling Wu, Yuan Fei Xu, Qiu Du · 发表于：DOAJ (DOAJ: Directory of Open Access Journals) · 年份：2022 · 被引用次数：62 · 研究领域：Bioactive natural compounds、Calcium signaling and nucleotide metabolism、Bioactive Compounds and Antitumor Agents

Yingda Lin,1,2,* Fuming He,2 Ling Wu,1 Yuan Xu,1 Qiu Du3,4,* 1Department of Pharmacy, the Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, 225012, People’s Republic of China; 2Medical College, Yangzhou University, Yangzhou, 225001, People’s Republic of China; 3Department of Neurosurgery, the Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, 225012, People’s Republic of China; 4Department of Central Laboratory, the Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, 225012, People’s Republic of China*These authors contributed equally to this workCorrespondence: Qiu Du, Department of Neurosurgery, the Affiliated Hospital of Yangzhou University, Yangzhou University, 368 Hanjiang Middle Road, Yangzhou, 225012, People’s Republic of China, Email 092102@yzu.edu.cn Yuan Xu, Department of pharmacy, the Affiliated Hospital of Yangzhou University, Yangzhou University, 368 Hanjiang Middle Road, Yangzhou, 225012, People’s Republic of China, Email feebyxuyuan@163.comAbstract: As The main effective monomer of the traditional Chinese medicine Sophora flavescens Ait, matrine has a broad scope of pharmacological activities such as anti-tumor, anti-inflammatory, analgesic, anti-fibrotic, anti-viral, anti-arrhythmia, and improving immune function. These actions explain its therapeutic effects in various types of tumors, cardiopathy, encephalomyelitis, allergic asthma, rheumatoid arthritis (RA), osteoporosis, and central ne...