Neuronal STAT3/HIF-1α/PTRF axis-mediated bioenergetic disturbance exacerbates cerebral ischemia-reperfusion injury via PLA2G4A

作者：Weili Jin, Jixing Zhao, Eryan Yang, Yunfei Wang, Qixue Wang, Ye Wu, Fei Tong, Yanli Tan, Junhu Zhou, Chunsheng Kang · 发表于：Theranostics · 年份：2022 · DOI：10.7150/thno.71029 · 被引用次数：97 · 研究领域：Cancer-related molecular mechanisms research、RNA modifications and cancer、Cancer, Hypoxia, and Metabolism

Our results thus identify that the STAT3/HIF-1α/PTRF-axis in neurons, aggravating cerebral I/R injury by regulating the activity and stability of PLA2G4A, might be a novel therapeutic target for ischemic stroke.