Clinical Value of Early-Pregnancy Glycated Hemoglobin, Fasting Plasma Glucose, and Body Mass Index in Screening Gestational Diabetes Mellitus

作者：Yanqin Lou, Xiang Li, Xuemei Gao, Huijun Jiang · 发表于：Laboratory Medicine · 年份：2022 · DOI：10.1093/labmed/lmac058 · 被引用次数：3 · 研究领域：Gestational Diabetes Research and Management、Pregnancy and preeclampsia studies、Pancreatic function and diabetes

OBJECTIVE: To investigate clinical values of early-pregnancy (8-13 weeks) glycated hemoglobin (HbA1c), fasting plasma glucose (FPG), and body mass index (BMI) in screening gestational diabetes mellitus (GDM). METHODS: A total of 1120 cases underwent a 75 g oral glucose tolerance test (OGTT), of which 216 cases with GDM were selected as the study group, and 278 cases without GDM were selected as the control group. FPG, HbA1c, and BMI in early pregnancy were measured. The correlation between FPG, HbA1c and BMI in early pregnancy and the incidence of GDM was analyzed by binary logistic regression, and the value of each index in predicting GDM alone or in combination was evaluated. RESULTS: FPG, HbA1c, and BMI in early pregnancy in the GDM group were higher than those in the control group, and the differences were statistically significant (P < .05). Binary logistic regression analysis showed that FPG, HbA1c, and BMI were risk factors for GDM in early pregnancy (odds ratio [OR] values were 3.374 [P < .05], 4.644 [P < .001], and 1.077 [P < .001], respectively). The area under the receiver operating characteristic (ROC) curve of FPG, glycated hemoglobin, and BMI in screening GDM for early pregnancy were 0.647, 0.661, and 0.608, respectively, while the area under the ROC curve of the combination of these 3 indicators was 0.736. CONCLUSION: We found that FPG, HbA1c, and BMI in early pregnancy might be the potential risk factors for the occurrence of GDM, and the combination of them h...