Use of quality‐of‐life instruments for people living with HIV: a global systematic review and meta‐analysis

作者：Ying Zhang, Christine He, Tessa Peasgood, Emily S. G. Hulse, Christopher K. Fairley, Graham Brown, Richard Ofori‐Asenso, Jason J. Ong · 发表于：Journal of the International AIDS Society · 年份：2022 · DOI：10.1002/jia2.25902 · 被引用次数：45 · 研究领域：HIV/AIDS Research and Interventions、HIV-related health complications and treatments、Health Systems, Economic Evaluations, Quality of Life

Abstract Introduction Due to the effectiveness of combined antiretroviral therapy and its growing availability worldwide, most people living with HIV (PLHIV) have a near‐normal life expectancy. However, PLHIV continue to face various health and social challenges that severely impact their health‐related quality‐of‐life (HRQoL). The UNAIDS Global AIDS Strategy discusses the need to optimize quality‐of‐life, but no guidance was given regarding which instruments were appropriate measures of HRQoL. This study aimed to review and assess the use of HRQoL instruments for PLHIV. Methods We conducted a global systematic review and meta‐analysis, searching five databases for studies published between January 2010 and February 2021 that assessed HRQoL among PLHIV aged 16 years and over. Multivariable regression analyses were performed to identify factors associated with the choice of HRQoL instruments. We examined the domains covered by each instrument. Random‐effects meta‐analysis was conducted to explore the average completion rates of HRQoL instruments. Results and discussion From 714 publications, we identified 65 different HRQoL instruments. The most commonly used instruments were the World Health Organization Quality‐of‐Life‐ HIV Bref (WHOQOL‐HIV BREF)—19%, Medical Outcome Survey‐HIV (MOS‐HIV)—17%, Short Form‐36 (SF‐36)—12%, European Quality‐of‐Life Instrument‐5 Dimension (EQ‐5D)—10%, World Health Organization Quality‐of‐Life Bref (WHOQOL BREF)—8%, Short Form‐12 (SF‐12)—7% and HIV...