DNA walker-amplified signal-on electrochemical aptasensors for prostate-specific antigen coupling with two hairpin DNA probe-based hybridization reaction

作者：Yuyu Zheng, Jinpeng Wang, Gen-Wang Chen, Meie Wang, Tebin Chen, Qiaohong Ke, Yajun Huang, Fan Cai, Rongfu Huang, Chun-mei Fan · 发表于：The Analyst · 年份：2022 · DOI：10.1039/d2an00327a · 被引用次数：7 · 研究领域：Advanced biosensing and bioanalysis techniques、Biosensors and Analytical Detection、Transplantation: Methods and Outcomes

. A good reproducibility with batch-to-batch errors was acquired for target PSA down to 11.5%. Non-target analytes did not interfere with the voltammetric signals of the electrochemical aptasensors. Meanwhile, 15 human serum specimens were measured with electrochemical aptasensors, and displayed well-matched results in comparison with the referenced human PSA enzyme-linked immunosorbant assay (ELISA) method. Significantly, this method provides a new horizon for the quantitative monitoring of low-concentration biomarkers or nucleic acids.