First live birth in China after cryopreserved ovarian tissue transplantation to prevent premature ovarian insufficiency

作者：Xiangyan Ruan, Juan Du, Dan Lu, W. Duan, Fang Jin, Wei­min Kong, Ying Wu, Yinmei Dai, Shengtao Yan, Chenghong Yin, Y. Li, Jiumei Cheng, Cuiyu Jia, X. Liu, Qingqing Wu, M. Gu, R. Ju, Xiyuan Xu, Yingchi Yang, Jiayan Jin, M. Korell, Markus Montag, Jana Liebenthron, A. O. Mueck · 发表于：Climacteric · 年份：2022 · DOI：10.1080/13697137.2022.2064215 · 被引用次数：17 · 研究领域：Reproductive Biology and Fertility、Ovarian function and disorders、Reproductive Health and Technologies

OBJECTIVE: This article reports the first live birth after cryopreserved ovarian tissue transplantation to prevent premature ovarian insufficiency in China. METHODS: A patient with myelodysplastic syndrome received ovarian tissue cryopreservation before hematopoietic stem cell transplantation, and six ovarian cortex strips were thawed and transplanted into her peritoneal pocket 2 years later. RESULTS: Pregnancy occurred spontaneously 27 months after grafting, and a healthy girl was born at 38 weeks gestation. Until now, the child has developed normally without any major diseases. CONCLUSIONS: We report the first live birth resulting from ovarian tissue cryopreservation and transplantation in China.