The emerging landscape of exosomal CircRNAs in solid cancers and hematological malignancies

作者：Qinfeng Zhou, Dacheng Xie, Rong Wang, Lianfang Liu, Yue Yu, Xinyi Tang, Yongxian Hu, Dawei Cui · 发表于：Biomarker Research · 年份：2022 · DOI：10.1186/s40364-022-00375-3 · 被引用次数：23 · 研究领域：Circular RNAs in diseases、Extracellular vesicles in disease、MicroRNA in disease regulation

Circular RNAs (circRNAs) are a type of recently discovered noncoding RNA. They exert their biological functions by competitively binding to microRNAs (miRNAs) as miRNA sponges, promoting gene transcription and participating in the regulation of selective splicing, interacting with proteins and being translated into proteins. Exosomes are derived from intracavitary vesicles (ILVs), which are formed by the inward budding of multivesicular bodies (MVBs), and exosome release plays a pivotal role in intercellular communication. Accumulating evidence indicates that circRNAs in exosomes are associated with solid tumor invasion and metastasis. Additionally, emerging studies in the last 1 ~ 2 years have revealed that exosomal circRNA also have effect on hematological malignancies. In this review, we outline the properties and biological functions of circRNAs and exosomes. In particular, we summarize in detail the mechanism and roles of exosomal circRNAs and highlight their application as novel biomarkers in malignant tumors.