Differential Diagnosis of Crohn’s Disease and Ulcerative Primary Intestinal Lymphoma: A Scoring Model Based on a Multicenter Study

作者：Hong Yang, Huimin Zhang, Wei Liu, Bei Tan, Tao Guo, Xiang Gao, Rui Feng, Kaichun Wu, Qian Cao, Zhihua Ran, Zhanju Liu, Naizhong Hu, Liangru Zhu, Yamin Lai, Congling Wang, Wei Han, Jiaming Qian · 发表于：Frontiers in Oncology · 年份：2022 · DOI：10.3389/fonc.2022.856345 · 被引用次数：6 · 研究领域：Lymphoma Diagnosis and Treatment、Inflammatory Bowel Disease、Microscopic Colitis

Background: Differential diagnosis of Crohn's disease (CD) and ulcerative primary intestinal lymphoma (UPIL) is a tough problem in clinical practice. Aims: Our study identified key differences between CD and UPIL patients and aimed to further establish a scoring model for differential diagnosis. Methods: A total of 91 CD and 50 UPIL patients from 9 tertiary inflammatory bowel disease centers were included. Univariate and multivariate analyses were used to determine significant markers for differentiating CD and UPIL. A differential scoring model was established by logistic regression analysis. Results: The differential model was based on clinical symptoms, endoscopic and imaging features that were assigned different scores: intestinal bleeding (-2 points), extraintestinal manifestation (2 points), segmental lesions (1 point), cobblestone sign (2 points), homogeneous enhancement (-1 point), mild enhancement (-1 point), engorged vasa recta (1 point). A total score of ≥1 point indicates CD, otherwise UPIL was indicated. This model produced an accuracy of 83.66% and an area under the ROC curve of 0.947. The area under the ROC curve for validation using the 10-fold validation method was 0.901. Conclusion: This study provided a convenient and useful model to differentiate CD from UPIL.