Advanced diffusion imaging to track progression in Parkinson’s disease, multiple system atrophy, and progressive supranuclear palsy

作者：Trina Mitchell, Bradley J. Wilkes, Derek B. Archer, Winston T. Chu, Stephen A. Coombes, Song Lai, Nikolaus R. McFarland, Michael S. Okun, Mieniecia L. Black, Ellen Herschel, Tanya Simuni, Cynthia L. Comella, Mitra Afshari, Tao Xie, Hong Li, Todd B. Parrish, Ajay S. Kurani, Daniel M. Corcos, David E. Vaillancourt · 发表于：NeuroImage Clinical · 年份：2022 · DOI：10.1016/j.nicl.2022.103022 · 被引用次数：38 · 研究领域：Parkinson's Disease Mechanisms and Treatments、Neurological disorders and treatments、Advanced Neuroimaging Techniques and Applications

Advanced diffusion imaging which accounts for complex tissue properties, such as crossing fibers and extracellular fluid, may detect longitudinal changes in widespread pathology in atypical Parkinsonian syndromes. We implemented fixel-based analysis, Neurite Orientation and Density Imaging (NODDI), and free-water imaging in Parkinson's disease (PD), multiple system atrophy (MSAp), progressive supranuclear palsy (PSP), and controls longitudinally over one year. Further, we used these three advanced diffusion imaging techniques to investigate longitudinal progression-related effects in key white matter tracts and gray matter regions in PD and two common atypical Parkinsonian disorders. Fixel-based analysis and free-water imaging revealed longitudinal declines in a greater number of descending sensorimotor tracts in MSAp and PSP compared to PD. In contrast, only the primary motor descending sensorimotor tract had progressive decline over one year, measured by fiber density (FD), in PD compared to that in controls. PSP was characterized by longitudinal impairment in multiple transcallosal tracts (primary motor, dorsal and ventral premotor, pre-supplementary motor, and supplementary motor area) as measured by FD, whereas there were no transcallosal tracts with longitudinal FD impairment in MSAp and PD. In addition, free-water (FW) and FW-corrected fractional anisotropy (FAt) in gray matter regions showed longitudinal changes over one year in regions that have previously shown cros...