Efficacy of MP-3 microperimeter biofeedback fixation training for low vision rehabilitation in patients with maculopathy

作者：Tianwei Qian, Xian Xu, Xinyi Liu, Manni Yen, Hao Zhou, Man-man MAO, Huiting Cai, Hangqi Shen, Xun Xu, Yuan-Yuan Gong, Suqin Yu · 发表于：BMC Ophthalmology · 年份：2022 · DOI：10.1186/s12886-022-02419-6 · 被引用次数：23 · 研究领域：Ophthalmology and Visual Impairment Studies、Glaucoma and retinal disorders、Retinal and Macular Surgery

BACKGROUND: To evaluate the efficacy of MP-3 microperimeter biofeedback fixation training (MBFT) in vision rehabilitation of low-vision patients affected by macular disease with central vision loss. METHODS: Seventeen eyes (7 age-related macular degeneration, 10 myopic maculopathy) of 17 patients were included in this prospective, interventional study. The preferred retinal locus was determined by comprehensive ophthalmoscopic fundus evaluation including fundus photography, autofluorescence, optical coherence tomography, and microperimetry. The rehabilitation consisted of three 10-min sessions per eye to be performed twice per week for 20 consecutive weeks using the MP-3 microperimeter. Best corrected visual acuity (BCVA), reading speed, mean central sensitivity, the percentages of fixation points within specified regions, bivariate contour ellipse area (BCEA) and the 25-item National Eye Institute visual function questionnaire (NEI-VFQ-25) were recorded pre- and post-training. RESULTS: The final BCVA, reading speed and mean central sensitivity all showed significant improvements after rehabilitation (P < 0.0001, P = 0.0013, and P = 0.0002, respectively). The percentages of fixation points located within 2° and 4° diameter circles both significantly increased after training (P = 0.0008 and P = 0.0007, respectively). The BCEA encompassing 68.2, 95.4, 99.6% of fixation points were all significantly decreased after training (P = 0.0038, P = 0.0022, and P = 0.0021, respectively)....