Racial and Ethnic Disparities in Multiple Sclerosis Prevalence

作者：Annette M. Langer-Gould, Edlin Grisell Gonzales, Jessica B. Smith, Bonnie H. Li, Lorene M. Nelson · 发表于：Neurology · 年份：2022 · DOI：10.1212/wnl.0000000000200151 · 被引用次数：120 · 研究领域：Multiple Sclerosis Research Studies、Polyomavirus and related diseases、Peripheral Neuropathies and Disorders

BACKGROUND AND OBJECTIVES: The goal of this work was to determine whether the prevalence of multiple sclerosis (MS) varies by race and ethnicity. METHODS: code for MS between January 1, 2008 and December 31, 2010 were reviewed. MS prevalence and 95% CIs stratified by age, sex, and race and ethnicity among 2010 members were estimated with binomial regression. Age- and sex-standardized prevalence was estimated according to the 2010 US Census population. RESULTS: We identified 3,863 patients with MS. The average age of patients with prevalent MS was 51.7 years (SD 13.1 years), and 76.8% were women. The female preponderance was more pronounced among Black (81.2%) and Asian (83.6%) than White (76.3%) or Hispanic (74.5%) individuals with MS. Age- and sex-standardized MS prevalence per 100,000 was similarly high among Black (225.8, 95% CI 207.1-244.5) and White (237.7, 95% CI 228.2-247.2) and significantly lower among Hispanic (69.9, 95% CI 64.4-75.5) and Asian (22.6, 95% CI 17.1-28.1) persons. MS prevalence was highest between the ages of 35 and 64 years and declined after 65 years of age across all racial and ethnic groups. Among adults 18 to 24 years of age, the crude MS prevalence was low but was highest among Black and Hispanic young adults, lower in White people, and lowest in Asian/Pacific Islander individuals (48.5, 25.0, 18.0, and 7.1 per 100,000, respectively). DISCUSSION: MS prevalence varies by race and ethnicity, being similarly high in White and Black and significantly...