Multivariate profile and acute-phase correlates of cognitive deficits in a COVID-19 hospitalised cohort

作者：Adam Hampshire, Doris A. Chatfield, Anne Manktelow MPhil, Amy Jolly, William Trender, Peter J. Hellyer, Martina Del Giovane, Virginia Newcombe, Joanne Outtrim, Ben Warne, Junaid Bhatti, Linda Pointon, Anne Elmer, Nyaradzai Sithole, John R. Bradley, Nathalie Kingston, Stephen Sawcer, Edward T. Bullmore, James B. Rowe, David Menon · 发表于：EClinicalMedicine · 年份：2022 · DOI：10.1016/j.eclinm.2022.101417 · 被引用次数：117 · 研究领域：Long-Term Effects of COVID-19、Intensive Care Unit Cognitive Disorders、Cancer-related cognitive impairment studies

Background Preliminary evidence has highlighted a possible association between severe COVID-19 and persistent cognitive deficits. Further research is required to confirm this association, determine whether cognitive deficits relate to clinical features from the acute phase or to mental health status at the point of assessment, and quantify rate of recovery. Methods 46 individuals who received critical care for COVID-19 at Addenbrooke's hospital between 10th March 2020 and 31st July 2020 (16 mechanically ventilated) underwent detailed computerised cognitive assessment alongside scales measuring anxiety, depression and post-traumatic stress disorder under supervised conditions at a mean follow up of 6.0 (± 2.1) months following acute illness. Patient and matched control ( N = 460) performances were transformed into standard deviation from expected scores, accounting for age and demographic factors using N = 66,008 normative datasets. Global accuracy and response time composites were calculated (G_SScore & G_RT). Linear modelling predicted composite score deficits from acute severity, mental-health status at assessment, and time from hospital admission. The pattern of deficits across tasks was qualitatively compared with normal age-related decline, and early-stage dementia. Findings COVID-19 survivors were less accurate (G_SScore=-0.53SDs) and slower (G_RT=+0.89SDs) in their responses than expected compared to their matched controls. Acute illness, but not chronic mental health,...