Direct Photoexcitation of Xanthate Anions for Deoxygenative Alkenylation of Alcohols

作者：Hongmei Guo, Bin‐Qing He, Xuesong Wu · 发表于：Organic Letters · 年份：2022 · DOI：10.1021/acs.orglett.2c00889 · 被引用次数：54 · 研究领域：Radical Photochemical Reactions、Sulfur-Based Synthesis Techniques、Catalytic C–H Functionalization Methods

In this report, we identify xanthate salts as a unique class of visible-light-excitable alkyl radical precursors that act simultaneously as strong photoreductants and alkyl radical sources. Upon direct photoexcitation of xanthate anions, efficient deoxygenative alkenylation and alkylation of a wide range of primary, secondary, and tertiary alcohols have been achieved via a one-pot protocol, avoiding any photocatalysts. This method exhibits a broad substrate scope and good functional group tolerance, enabling late-stage functionalization of complex molecules.