Pilot trial using mass field-releases of sterile males produced with the incompatible and sterile insect techniques as part of integrated Aedes aegypti control in Mexico

作者：Abdiel Martín-Park, Azael Che‐Mendoza, Yamili Contreras‐Perera, Silvia Pérez-Carrillo, Henry Puerta‐Guardo, Josué Villegas‐Chim, Guillermo Guillermo-May, Anuar Medina‐Barreiro, Hugo Delfín‐González, Rosa Eugenia Méndez-Vales, Santos Vázquez-Narvaez, Jorge Palacio-Vargas, Fabián Correa‐Morales, Guadalupe Ayora‐Talavera, Norma Pavía‐Ruz, Xiao Liang, Ping Fu, Dongjing Zhang, Xiao Hua Wang, María Eugenia Toledo-Romaní, Zhiyong Xi, Gonzalo M. Vazquez‐Prokopec, Pablo Manrique‐Saide · 发表于：PLoS neglected tropical diseases · 年份：2022 · DOI：10.1371/journal.pntd.0010324 · 被引用次数：90 · 研究领域：Insect symbiosis and bacterial influences、Mosquito-borne diseases and control、Parasitic Diseases Research and Treatment

BACKGROUND: The combination of Wolbachia-based incompatible insect technique (IIT) and radiation-based sterile insect technique (SIT) can be used for population suppression of Aedes aegypti. Our main objective was to evaluate whether open-field mass-releases of wAlbB-infected Ae. aegypti males, as part of an Integrated Vector Management (IVM) plan led by the Mexican Ministry of Health, could suppress natural populations of Ae. aegypti in urbanized settings in south Mexico. METHODOLOGY/PRINCIPAL FINDINGS: We implemented a controlled before-and-after quasi-experimental study in two suburban localities of Yucatan (Mexico): San Pedro Chimay (SPC), which received IIT-SIT, and San Antonio Tahdzibichén used as control. Release of wAlbB Ae. aegypti males at SPC extended for 6 months (July-December 2019), covering the period of higher Ae. aegypti abundance. Entomological indicators included egg hatching rates and outdoor/indoor adult females collected at the release and control sites. Approximately 1,270,000 lab-produced wAlbB-infected Ae. aegypti males were released in the 50-ha treatment area (2,000 wAlbB Ae. aegypti males per hectare twice a week in two different release days, totaling 200,000 male mosquitoes per week). The efficacy of IIT-SIT in suppressing indoor female Ae. aegypti density (quantified from a generalized linear mixed model showing a statistically significant reduction in treatment versus control areas) was 90.9% a month after initiation of the suppression phase, 4...