Comparison of switching to 6-week dosing of natalizumab versus continuing with 4-week dosing in patients with relapsing-remitting multiple sclerosis (NOVA): a randomised, controlled, open-label, phase 3b trial

作者：John F. Foley, Gilles Louis Defer, Lana Zhovtis Ryerson, Jeffrey Allen Cohen, Douglas Lorne Arnold, Helmut Butzkueven, Gary Cutter, Gavin Giovannoni, Joep Killestein, Heinz Wiendl, Karen Vossen Smirnakis, Shan Xiao, George Y. X. Kong, Robert Kuhelj, Nolan Campbell, Anneke van der Walt, Chris Dwyer, Katherine A. Buzzard, Judith M. Spies, John Parratt, Vincent Van Pesch, Barbara M. P. Willekens, Gaetano Perrotta, Emmanuel J. Bartholome, François Grand’Maison, Francois Henri Jacques, Paul Steven Giacomini, Reza Vosoughi, Jean-Marc Girard, Jerome De Seze, Christine Lebrun‐Frénay, Aurélie Ruet, David Axel Laplaud, Gerd Reifschneider, Bert Wagner, Sebastian Bernhard Rauer, Refik Pul, Maria Seipelt, Achim Berthele, Luisa Klotz, Boris-Alexander Kallmann, Friedemann Paul, Anat Achiron, Giacomo Lus, Diego Centonze, Francesco Patti, Luigi Maria Edoardo Grimaldi, Raymond Hupperts, Stephan T F M Frequin, Jiske Fermont, Sara Eichau Madueño, Ana Alonso, Lucienne Costa-Frossard França, Jose Eustasio Meca-Lallana, Luís Brieva, Owen Rhys Pearson, David J. Rog, Nikolaos Evangelou, Azza Ismail, Ellen S. Lathi, Edward Fox, Thomas P. Leist, Jacob A. Sloane, Gregory F. Wu, Bhupendra Odhavji Khatri, Brian Steingo, Ben W. Thrower, Mark Gudesblatt, Jonathan Calkwood, Daniel S. Bandari, John Scagnelli, Christopher C. LaGanke, Derrick S. Robertson, Lucas B. Kipp, Martin Belkin, STANLEY L. COHAN, Lawrence Goldstick, Ardith Courtney, Wendy Vargas, Andrew Sylvester, Jayshri Srinivasan, Meena Kannan, MaryAnn Picone, Jeffrey English, Salvatore Q. Napoli, Roumen D. Balabanov, Islam Zaydan, Jacqueline A. Nicholas, Jeffrey Kaplan, FRED D. LUBLIN, Emily Riser, Tamara Miller, Enrique Álvarez, Sibyl E. Wray, Jeffrey B. Gross, Siddharama Pawate, Carrie M. Hersh, Lucas H. McCarthy, Heidi J. Crayton, Jennifer S. Graves · 发表于：The Lancet Neurology · 年份：2022 · DOI：10.1016/s1474-4422(22)00143-0 · 被引用次数：118 · 研究领域：Polyomavirus and related diseases、Multiple Sclerosis Research Studies、Brain Metastases and Treatment