A Bioluminescent Probe for Detecting Norepinephrine in Vivo

作者：Zeping Zuo, Ting Kang, Shilong Hu, Wuyue Su, Yu Gan, Zhuang Miao, Hanqing Zhao, Ping Feng, Bowen Ke, Minyong Li · 发表于：Analytical Chemistry · 年份：2022 · DOI：10.1021/acs.analchem.2c00460 · 被引用次数：23 · 研究领域：Photoreceptor and optogenetics research、Nicotinic Acetylcholine Receptors Study、Analytical Chemistry and Sensors

High Resolution Image Download MS PowerPoint Slide As a neurotransmitter, norepinephrine (NE) is critical for psychiatric conditions, neurodegenerative diseases, and pheochromocytoma. A real-time and noninvasive method for the detection of NE as a tracer to investigate the NE-relevant disease treatment process is urgently desirable. Herein, we successfully developed a turn-on NE bioluminescent probe (NBP), which was grounded on p -toluenethiol deprotectrf by nucleophilic substitution. Compared with other analytes, the NBP exhibited high sensitivity and selectivity in vitro . More importantly, the NBP provides a promising strategy for in vivo imaging of NE in living animals with noninvasive visualization and real-time features.