Global magnitude of encephalitis burden and its evolving pattern over the past 30 years

作者：Hao Wang, Shaohua Zhao, Shengjun Wang, Yue Zheng, Shaohua Wang, Hui Chen, Jiaojiao Pang, Juan Ma, Xiaorong Yang, Yuguo Chen · 发表于：Journal of Infection · 年份：2022 · DOI：10.1016/j.jinf.2022.04.026 · 被引用次数：96 · 研究领域：Herpesvirus Infections and Treatments、Mosquito-borne diseases and control、Infectious Encephalopathies and Encephalitis

OBJECTIVE: We aimed to estimate the spatiotemporal patterns of the encephalitis burden along with its attributable risk factors at the national, regional, and global levels, which may be helpful in guiding targeted prevention and treatment programs. METHODS: Based on available data sources, the incidence, mortality, and disability-adjusted life years (DALYs) of encephalitis in 204 countries and regions from 1990 to 2019 were reconstructed by the Global Burden of Disease Study 2019 using the Cause of Death Ensemble model, spatiotemporal Gaussian process regression, and DisMod-MR 2.1. We conducted a systematic analysis on the epidemiological characteristics of encephalitis in detail by gender, region, and age over the past three decades. RESULTS: Globally, 1,444,720 incident cases, 89,900 deaths, and 4.80 million DALYs related to encephalitis were estimated in 2019. The age-standardized incidence rate and age-standardized mortality rate (ASMR) decreased from 23.17 and 2.18 to 19.33 and 1.19 per 100,000 person-years over the past 30 years, respectively. However, beginning in 2011-2013, the burden of encephalitis has shown an inflection point, with a further decline of the ASRs ceasing. Lower socio-demographic index (SDI) regions in South Asia, Western and Eastern Sub-Saharan Africa had the highest burden of encephalitis in 2019. During the past three decades, most countries of South Asia achieved significant control of the burden. In contrast, developed countries with a higher S...