What Can Mercury Teach Us About Membranous Nephropathy and Minimal Change Disease?

作者：Tiffany Caza, Laith Al‐Rabadi · 发表于：Kidney International Reports · 年份：2022 · DOI：10.1016/j.ekir.2022.04.078 · 被引用次数：13 · 研究领域：Renal Diseases and Glomerulopathies、Muscle and Compartmental Disorders、Biomedical Research and Pathophysiology

From clinical associations of environmental exposure beginning with the story of cationic bovine serum in pediatric membranous nephropathy (MN) more than a decade ago1 and recently to the association of lipoic acid with NELL1-associated MN,2 the impact of environment in triggering autoimmunity warrants a fresh examination given the increased influence of anthropogenic factors on the development of glomerular disease. Repeated exposure to heavy metal compounds through pollution, cosmetics, vaccines, and manufacturing processes is associated with nephrotoxicity, which can manifest as minimal change disease (MCD) or MN.