Associations of systemic inflammation markers with identification of pulmonary nodule and incident lung cancer in Chinese population

作者：Ting Tian, Jing Lü, Wei Zhao, Zhongming Wang, Hai Xu, Yuqing Ding, Wen Guo, Pei Qin, Wenfang Zhu, Ci Song, Hongxia Ma, Qun Zhang, Hongbing Shen · 发表于：Cancer Medicine · 年份：2022 · DOI：10.1002/cam4.4606 · 被引用次数：58 · 研究领域：Inflammatory Biomarkers in Disease Prognosis、Cancer Immunotherapy and Biomarkers、Lung Cancer Diagnosis and Treatment

OBJECTIVES: Neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and systemic immune-inflammation index (SII), easily accessible systemic inflammation response parameters, were reported to associate with poor lung cancer prognosis. However, research on the effects of these markers on the risk of positive nodules (PNs) and lung cancer is limited. METHODS: Participants in this retrospective study were those who had their first computed tomography (CT) screening at Jiangsu Province Hospital's Health Promotion Center between January 1, 2017 and December 31, 2020. We identified PNs (≥6 mm in diameter) from free text of CT reports and lung cancer from medical records. Multivariate logistic analysis was used to assess the association between NLR, PLR, or SII and PNs or lung cancer. RESULTS: > 0.05). Compared with low quintile, participants with top quintiles of NLR, PLR or SII had an increased risk of PNs, with the adjusted ORs of 1.19 (1.11-1.28), 1.11 (1.04-1.19) or 1.11 (1.03-1.18), respectively. Meanwhile, NLR showed the U-shaped relationship with lung cancer, with adjusted ORs of 1.40 (1.08-1.81) comparing highest NLR quintile to the third quintile. The high PLR and SII showed significantly associated with lung cancer with adjusted ORs of 1.29 (0.99-1.68) and 1.35 (1.04-1.74) comparing to the lowest quintile. CONCLUSIONS: The high levels of systemic inflammation markers were associated with the risk of positive pulmonary nodules and lung cancer, which sugge...