Therapeutic Approaches of Ryanodine Receptor-Associated Heart Diseases

作者：Norbert Szentandrássy, Zsuzsanna Magyar, Judit Ildikó Hevesi, Tamás Bányász, Péter P. Nánási, János Almássy · 发表于：International Journal of Molecular Sciences · 年份：2022 · DOI：10.3390/ijms23084435 · 被引用次数：26 · 研究领域：Cardiac electrophysiology and arrhythmias、Ion channel regulation and function、Cardiovascular Effects of Exercise

Cardiac diseases are the leading causes of death, with a growing number of cases worldwide, posing a challenge for both healthcare and research. Therefore, the most relevant aim of cardiac research is to unravel the molecular pathomechanisms and identify new therapeutic targets. Cardiac ryanodine receptor (RyR2), the Ca2+ release channel of the sarcoplasmic reticulum, is believed to be a good therapeutic target in a group of certain heart diseases, collectively called cardiac ryanopathies. Ryanopathies are associated with the impaired function of the RyR, leading to heart diseases such as congestive heart failure (CHF), catecholaminergic polymorphic ventricular tachycardia (CPVT), arrhythmogenic right ventricular dysplasia type 2 (ARVD2), and calcium release deficiency syndrome (CRDS). The aim of the current review is to provide a short insight into the pathological mechanisms of ryanopathies and discuss the pharmacological approaches targeting RyR2.