Polysubstituted Cyclopentene Benzamides and Dianthramide Alkaloids from Delphinium anthriscifolium Hance

作者：Qi-Jing Fan, Gang-Zhong Zhou, Chuchu Xi, Bo Niu, Yan-Gang Cao, Fan Zhang, C. Benjamin Naman, Chunlei Zhang, Zhengyu Cao · 发表于：Journal of Natural Products · 年份：2022 · DOI：10.1021/acs.jnatprod.2c00107 · 被引用次数：11 · 研究领域：Plant-based Medicinal Research、Berberine and alkaloids research、Pharmacological Effects of Natural Compounds

Thirteen new benzamide alkaloids, delphiniumines A–M ( 1 – 13 ), together with one known analogue ( 14 ), were isolated from Delphinium anthriscifolium Hance. All of the structures were determined by spectroscopic and spectrometric analyses. Absolute configuration for 1 was established using experimental and calculated ECD data, as well as by X-ray crystallography analysis. Compound 1 possesses a previously undescribed polysubstituted cyclopentene carbon framework. Compound 2 was isolated as an artifact from 1 during the extraction process. Compound 7 is glycosylated with a β- D -glucose unit. Compound 13 bears a chlorine substituent. At a concentration of 10 μM, compounds 6, 8, and 10 – 12 suppressed LPS-induced NO production in RAW264.7 cells with inhibition rates ranging from 40.3% to 78.8%.