GBP2 facilitates the progression of glioma via regulation of KIF22/EGFR signaling

作者：Yeqing Ren, Biao Yang, Geng Guo, Jianping Zhang, Yanqi Sun, Dong Liu, Shihao Guo, Yongqiang Wu, Xiaogang Wang, Shule Wang, Wenju Zhang, Xiaolong Guo, Xuepeng Li, Li Ren, Jianhang He, Zihan Zhou · 发表于：Cell Death Discovery · 年份：2022 · DOI：10.1038/s41420-022-01018-0 · 被引用次数：25 · 研究领域：Microtubule and mitosis dynamics、Glioma Diagnosis and Treatment、Ubiquitin and proteasome pathways

Identifying the mechanism of glioma progression is critical for diagnosis and treatment. Although studies have shown that guanylate-binding protein 2(GBP2) has critical roles in various cancers, its function in glioma is unclear. In this work, we demonstrate that GBP2 has high expression levels in glioma tissues. In glioma cells, depletion of GBP2 impairs proliferation and migration, whereas overexpression of GBP2 enhances proliferation and migration. Regarding the mechanism, we clarify that epidermal growth factor receptor (EGFR) signaling is regulated by GBP2, and also demonstrate that GBP2 interacts directly with kinesin family member 22(KIF22) and regulates glioma progression through KIF22/EGFR signaling in vitro and in vivo. Therefore, our study provides new insight into glioma progression and paves the way for advances in glioma treatment.