Construction of emissive ruthenium(II) metallacycle over 1000 nm wavelength for in vivo biomedical applications

作者：Yuling Xu, Chonglu Li, Shuai Lu, Zhi-Zheng Wang, Shuang Liu, Xiujun Yu, Xiaopeng Li, Yao Sun · 发表于：Nature Communications · 年份：2022 · DOI：10.1038/s41467-022-29572-2 · 被引用次数：194 · 研究领域：Nanoparticle-Based Drug Delivery、Nanoplatforms for cancer theranostics、Lanthanide and Transition Metal Complexes

Although Ru(II)-based agents are expected to be promising candidates for substituting Pt-drug, their in vivo biomedical applications are still limited by the short excitation/emission wavelengths and unsatisfactory therapeutic efficiency. Herein, we rationally design a Ru(II) metallacycle with excitation at 808 nm and emission over 1000 nm, namely Ru1085, which holds deep optical penetration (up to 6 mm) and enhanced chemo-phototherapy activity. In vitro studies indicate that Ru1085 exhibits prominent cell uptake and desirable anticancer capability against various cancer cell lines, especially for cisplatin-resistant A549 cells. Further studies reveal Ru1085 induces mitochondria-mediated apoptosis along with S and G2/M phase cell cycle arrest. Finally, Ru1085 shows precise NIR-II fluorescence imaging guided and long-term monitored chemo-phototherapy against A549 tumor with minimal side effects. We envision that the design of long-wavelength emissive metallacycle will offer emerging opportunities of metal-based agents for in vivo biomedical applications.