Comprehensive Analysis of the Nocardia cyriacigeorgica Complex Reveals Five Species-Level Clades with Different Evolutionary and Pathogenicity Characteristics

作者：Shuai Xu, Ming Wei, Gang Li, Zhenpeng Li, Zhenpeng Li, Yanlin Che, Lichao Han, Wei Jia, Fang Li, Dan Li, Zhenjun Li, Zhenjun Li · 发表于：mSystems · 年份：2022 · DOI：10.1128/msystems.01406-21 · 被引用次数：20 · 研究领域：Actinomycetales infections and treatment、Infectious Diseases and Mycology、Phytoplasmas and Hemiptera pathogens

is not a single species but is composed of five closely related species. In addition, we discovered that these five species differ in many ways, involving selection pressure, horizontal gene transfer, functional capacity, pathogenicity, and antibiotic resistance. Overall, our work provides important clues in dissecting the evolution, genetic diversity, and pathogenicity of NCC, thereby advancing prevention measures against these infections.