N -Butyl-4-hydrazino-1,8-naphthalimide-Loaded Chitosan Self-Assembled Nanoparticles as Fluorescent Ratiometric Chemosensors for Detection of Formaldehyde

作者：Lingna Yang, Qingxin Han, Xiaoling Ling, Yansong Wang, Miaohua Li, Qingliang Chen, Xuechuan Wang · 发表于：ACS Applied Nano Materials · 年份：2022 · DOI：10.1021/acsanm.2c01320 · 被引用次数：18 · 研究领域：Molecular Sensors and Ion Detection、Luminescence and Fluorescent Materials、Sulfur Compounds in Biology

Formaldehyde (FA) is a typical volatile organic compound widely used in diverse fields, including decoration materials, textiles, and chemical processing. However, FA is also a carcinogen and poses a serious threat to human health. Therefore, the development of a rapid and efficient method for the detection of FA is a pressing concern. Herein, a kind of self-assembled fluorescent nanoparticle ( CS-OCH 3 @NBHN ) was designed and constructed by using a chitosan-based fluorescent probe ( CS-OCH 3 ) as a carrier, which was loaded with a small-molecule FA fluorescent probe. The nanoprobe CS-OCH 3 @NBHN proved to be rapid and highly sensitive for FA recognition, with a ratiometric fluorescence response of less than 10 min and a detection limit of 66.29 nM. In addition, the probe exhibited high selectivity to FA, good anti-interference ability, and a wide pH application range (pH 3.0–11.0). More importantly, it is applied for the sensitive detection of FA in aqueous solution, air, leather samples, and living cells.