Enhancing Metabolic Efficiency through Optimizing Metabolizable Protein Profile in a Time Progressive Manner with Weaned Goats as a Model: Involvement of Gut Microbiota

作者：Jian Wu, Xiaoli Zhang, Min Wang, Chuanshe Zhou, Jinzhen Jiao, Zhiliang Tan · 发表于：Microbiology Spectrum · 年份：2022 · DOI：10.1128/spectrum.02545-21 · 被引用次数：22 · 研究领域：Gut microbiota and health、Ruminant Nutrition and Digestive Physiology、Diet and metabolism studies

Precise dietary intervention in early-life gastrointestinal microbiota has significant implications in the long-life productivity and health of young ruminants, as well as in lowering their environmental footprint. Here, using weaned goats as a model, we report that animals adapted to high rumen-undegradable protein diet in a dynamic manner by enriching fecal community that could effectively move toward and scavenge nutrients such as glucose and amino acids and, thereafter, elicit butyrate and BCAA production. Meanwhile, the three dynamic assembly trajectories in fecal microbiota highlight the importance of taking microbiota dynamics into account. Our findings systematically reported when, which, and how the fecal microbiome responded to metabolizable protein profile intervention in young ruminants and laid a foundation for improving the productivity and health of livestock due to the host-microbiota interplay.