Streamlined Alkylation via Nickel-Hydride-Catalyzed Hydrocarbonation of Alkenes

作者：Zhikun Zhang, Srikrishna Bera, Chao Fan, Xile Hu · 发表于：Journal of the American Chemical Society · 年份：2022 · DOI：10.1021/jacs.1c13482 · 被引用次数：193 · 研究领域：Catalytic C–H Functionalization Methods、Catalytic Cross-Coupling Reactions、Asymmetric Hydrogenation and Catalysis

-hybridized carbons are desirable in drug discovery. Nickel-catalyzed hydrocarbonation of alkenes is a potentially efficient method to synthesize these compounds. By using abundant, readily available, and stable alkenes as pro-nucleophiles, these reactions can have broad scope and high functional group tolerance. However, this methodology is still in an early stage of development, as the first efficient examples were reported only in 2016. Herein, we summarize the progress of this emerging field, with an emphasis on enantioselective reactions. We highlight major developments, critically discuss a wide range of possible mechanisms, and offer our perspective of the state and challenges of the field. We hope this Perspective will stimulate future works in this area, making the methodology widely applicable in organic synthesis.