Application of the Spin-Center Shift in Organic Synthesis

作者：Feng‐Lian Zhang, Bin Li, K. N. Houk, Yi‐Feng Wang · 发表于：JACS Au · 年份：2022 · DOI：10.1021/jacsau.2c00051 · 被引用次数：79 · 研究领域：Radical Photochemical Reactions、Catalytic C–H Functionalization Methods、Oxidative Organic Chemistry Reactions

Spin-center shift (SCS) is a radical process involving 1,2-radical translocation along with a two-electron ionic movement, such as elimination of an adjacent leaving group. Such a process was initially observed in some important biochemical transformations, and the unique property has also attracted considerable interest in synthetic chemistry. Experimental, kinetic, as well as computational studies have been performed, and a series of useful radical transformations have been developed and applied in organic synthesis based on SCS processes in the last 20 years. This Perspective is an overview of radical transformations involving the SCS mechanism.