Does vitamin D have an effect on osseointegration of dental implants? A systematic review

作者：Joscha Gabriel Werny, Keyvan Sagheb, Leonardo Díaz, Peer Wolfgang Kämmerer, Bilal Al‐Nawas, Eik Schiegnitz · 发表于：International Journal of Implant Dentistry · 年份：2022 · DOI：10.1186/s40729-022-00414-6 · 被引用次数：55 · 研究领域：Vitamin D Research Studies、Bone health and osteoporosis research、Bone Tissue Engineering Materials

PURPOSE: The aim of this study was to systematically review the available evidence to evaluate the efficacy of vitamin D supplementation or vitamin D depletion on the osseointegration of implants in animals and humans. METHODS: The focus questions addressed were "Do vitamin D deficient subjects treated with (dental) implants have an inferior osseointegration than subjects with adequate serum vitamin D level?" and "Do vitamin D supplemented subjects treated with (dental) implants have a superior osseointegration than subjects with adequate serum vitamin D level?" Humans and animals were considered as subjects in this study. Databases were searched from 1969 up to and including March 2021 using different combination of the following terms: "implant", "bone to implant contact", "vitamin D" and "osseointegration". Letters to the editor, historic reviews, commentaries and articles published in languages other than English and German were excluded. The pattern of the present systematic review was customize to primarily summarize the pertinent data. RESULTS: Thirteen experimental studies with animals as subject, two clinical studies and three case reports, with humans as subjects, were included. The amount of inserted titanium implants ranged between 24 and 1740. Results from three animal studies showed that vitamin D deficiency has a negative effect on new bone formation and/or bone to implant contact (BIC). Eight animal studies showed that vitamin D supplementation has a enhancing...