A G-Protein-Coupled Receptor Modulates Gametogenesis via PKG-Mediated Signaling Cascade in Plasmodium berghei

作者：Pengpeng Wang, Xuefeng Jiang, Liying Zhu, Dan Zhou, Mingyang Hong, Lu He, Lumeng Chen, Shijie Yao, Yan Zhao, Guang Chen, Chengqi Wang, Liwang Cui, Yaming Cao, Xiaotong Zhu · 发表于：Microbiology Spectrum · 年份：2022 · DOI：10.1128/spectrum.00150-22 · 被引用次数：26 · 研究领域：Malaria Research and Control、Neurobiology and Insect Physiology Research、Complement system in diseases

Environmental changes from humans to mosquitoes activate gametogenesis of the malaria parasite, an obligative process for parasite transmission, but how the signals are relayed remains poorly understood. Here, we show the identification of a Plasmodium G-protein-coupled receptor, GPR180, and the characterization of its function in gametogenesis.