Schizophrenia Imaging Signatures and Their Associations With Cognition, Psychopathology, and Genetics in the General Population

作者：Ganesh B. Chand, Pankhuri Singhal, Dominic Dwyer, Junhao Wen, Güray Erus, Jimit Doshi, Dhivya Srinivasan, Elizabeth Mamourian, Erdem Varol, Aristeidis Sotiras, Gyujoon Hwang, Paola Dazzan, René S. Kahn, Hugo G. Schnack, Marcus V. Zanetti, Eva Meisenzahl, Geraldo F. Busatto, Benedicto Crespo‐Facorro, Christos Pantelis, Stephen J. Wood, Chuanjun Zhuo, Russell T. Shinohara, Haochang Shou, Yong Fan, Nikolaos Koutsouleris, Antonia N. Kaczkurkin, Tyler M. Moore, Anurag Verma, Monica E. Calkins, Raquel E. Gur, Ruben C. Gur, Marylyn D. Ritchie, Theodore D. Satterthwaite, Daniel H. Wolf, Christos Davatzikos · 发表于：American Journal of Psychiatry · 年份：2022 · DOI：10.1176/appi.ajp.21070686 · 被引用次数：51 · 研究领域：Schizophrenia research and treatment、Genetic Associations and Epidemiology、Functional Brain Connectivity Studies

OBJECTIVE: The prevalence and significance of schizophrenia-related phenotypes at the population level is debated in the literature. Here, the authors assessed whether two recently reported neuroanatomical signatures of schizophrenia-signature 1, with widespread reduction of gray matter volume, and signature 2, with increased striatal volume-could be replicated in an independent schizophrenia sample, and investigated whether expression of these signatures can be detected at the population level and how they relate to cognition, psychosis spectrum symptoms, and schizophrenia genetic risk. METHODS: This cross-sectional study used an independent schizophrenia-control sample (N=347; ages 16-57 years) for replication of imaging signatures, and then examined two independent population-level data sets: typically developing youths and youths with psychosis spectrum symptoms in the Philadelphia Neurodevelopmental Cohort (N=359; ages 16-23 years) and adults in the UK Biobank study (N=836; ages 44-50 years). The authors quantified signature expression using support-vector machine learning and compared cognition, psychopathology, and polygenic risk between signatures. RESULTS: Two neuroanatomical signatures of schizophrenia were replicated. Signature 1 but not signature 2 was significantly more common in youths with psychosis spectrum symptoms than in typically developing youths, whereas signature 2 frequency was similar in the two groups. In both youths and adults, signature 1 was assoc...