Physical Activity and Cognition in Sedentary Older Adults: A Systematic Review and Meta-Analysis

作者：Yan Zhao, Yan Li, Lijing Wang, Zihe Song, Tengsen Di, Xinyi Dong, Xiaohan Song, Xintong Han, Yanyan Zhao, Bingfei Wang, Huixian Cui, Haiying Chen, Sha Li · 发表于：Journal of Alzheimer s Disease · 年份：2022 · DOI：10.3233/jad-220073 · 被引用次数：41 · 研究领域：Physical Activity and Health、Dementia and Cognitive Impairment Research、Older Adults Driving Studies

BACKGROUND: Epidemiologic evidence suggests that physical activity benefits cognition, but results from randomized trials in sedentary individuals are limited and inconsistent. OBJECTIVE: To evaluate the effects of physical activity on cognition among sedentary older adults. OBJECTIVE: A systematic literature search for eligible studies published up to January 1, 2021, was performed on six international (PubMed, Cochrane Library, Web of Science, Sinomed, FMRS, and OVID) and three Chinese databases (Wanfang, China National Knowledge Infrastructure, and VIP). We estimated the effect of physical activity on the cognition of sedentary elderly by standardized mean differences (SMD) and 95% confidence intervals (CI) using a random-effects model. We evaluated publication bias using funnel plots and heterogeneity using I2 statistics. Subgroup analyses were conducted by baseline cognition, intervention duration, activity type, and country. RESULTS: Seven randomized controlled trials (RCTs) comprising 321 (experimental group, 164; control group, 157) sedentary older adults were included in the meta-analysis. Physical activity significantly improved cognition in sedentary elderly adults compared with controls (SMD: 0.50, 95% CI:0.09-0.92). Subgroup analyses showed significant effects of baseline cognition impairment (SMD: 9.80, 95% CI: 5.81-13.80), intervention duration > 12 weeks (SMD: 2.85, 95% CI: 0.73-4.96), aerobic exercise (SMD: 0.74, CI: 0.19-1.29), and countries other than the U...