Asymmetric Synthesis of Pyrrolidines via Oxetane Desymmetrization

作者：Renwei Zhang, Meng Sun, Qiaolin Yan, Xingbang Lin, Xin Li, Xin Fang, Herman H. Y. Sung, Ian D. Williams, Jianwei Sun · 发表于：Organic Letters · 年份：2022 · DOI：10.1021/acs.orglett.2c00564 · 被引用次数：22 · 研究领域：Asymmetric Synthesis and Catalysis、Synthesis and Catalytic Reactions、Synthetic Organic Chemistry Methods

Asymmetric synthesis of chiral pyrrolidines bearing an all-carbon quaternary stereocenter in the 3-position remains challenging. Herein we report two efficient protocols by means of oxetane desymmetrization, featuring the use of a readily available tert -butylsulfinamide chiral auxiliary and a catalytic system with chiral phosphoric acid as the source of chirality, respectively.