Challenges to Improve Bone Healing Under Diabetic Conditions

作者：Yi‐Ling Chen, Yue Zhou, Jie Lin, Shiwen Zhang · 发表于：Frontiers in Endocrinology · 年份：2022 · DOI：10.3389/fendo.2022.861878 · 被引用次数：44 · 研究领域：Laser Applications in Dentistry and Medicine、Bone health and osteoporosis research、Diabetic Foot Ulcer Assessment and Management

Diabetes mellitus (DM) can affect bone metabolism and the bone microenvironment, resulting in impaired bone healing. The mechanisms include oxidative stress, inflammation, the production of advanced glycation end products (AGEs), etc. Improving bone healing in diabetic patients has important clinical significance in promoting fracture healing and improving bone integration. In this paper, we reviewed the methods of improving bone healing under diabetic conditions, including drug therapy, biochemical cues, hyperbaric oxygen, ultrasound, laser and pulsed electromagnetic fields, although most studies are in preclinical stages. Meanwhile, we also pointed out some shortcomings and challenges, hoping to provide a potential therapeutic strategy for accelerating bone healing in patients with diabetes.