Arylboronic Acid Deborylation Deuteration via Synergistic Thiol, Lewis Base, and Photoredox Catalysis

作者：Jianyang Dong, Mo Yu, Fuyang Yue, Hongjian Song, Yuxiu Liu, Linan Wu, Duanyun Si, Cheng Yang, Guang Yang, Qingmin Wang · 发表于：Organic Letters · 年份：2022 · DOI：10.1021/acs.orglett.2c00722 · 被引用次数：19 · 研究领域：Chemical Reactions and Isotopes、Asymmetric Hydrogenation and Catalysis、Chemical Synthesis and Analysis

A mild method for the deborylation deuteration of arylboronic acids with D 2 O, mediated by the synergistic combination of a thiol, a Lewis base, and photoredox catalysis, is reported. This reaction showed a broad substrate scope, excellent deuterium incorporation, and functional group tolerance. Therefore, this method is practical for the site-selective D-labeling of bioactive molecules and drug molecules.