Rates of respiratory syncytial virus (RSV)-associated hospitalization among adults with congestive heart failure—United States, 2015–2017

作者：Stephanie A Kujawski, MICHAEL D. WHITAKER, Matthew D. Ritchey, Arthur Lawrence Reingold, Shua J. Chai, Evan J. Anderson, Kyle P. Openo, Maya Monroe, Patricia A. Ryan, Erica Bye, Kathryn J. Como-Sabetti, Grant R. Barney, Alison Muse, Nancy M. Bennett, Christina B. Felsen, Ann R Thomas, Courtney Crawford, H. Keipp Talbot, William Schaffner, Susan I. Gerber, Gayle Langley, Lindsay Kim · 发表于：PLoS ONE · 年份：2022 · DOI：10.1371/journal.pone.0264890 · 被引用次数：74 · 研究领域：Respiratory viral infections research、Animal Virus Infections Studies、COVID-19 Clinical Research Studies

BACKGROUND: Respiratory syncytial virus (RSV) can cause severe disease in adults with cardiopulmonary conditions, such as congestive heart failure (CHF). We quantified the rate of RSV-associated hospitalization in adults by CHF status using population-based surveillance in the United States. METHODS: Population-based surveillance for RSV (RSV-NET) was performed in 35 counties in seven sites during two respiratory seasons (2015-2017) from October 1-April 30. Adults (≥18 years) admitted to a hospital within the surveillance catchment area with laboratory-confirmed RSV identified by clinician-directed testing were included. Presence of underlying CHF was determined by medical chart abstraction. We calculated overall and age-stratified (<65 years and ≥65 years) RSV-associated hospitalization rates by CHF status. Estimates were adjusted for age and the under-detection of RSV. We also report rate differences (RD) and rate ratios (RR) by comparing the rates for those with and without CHF. RESULTS: 2042 hospitalized RSV cases with CHF status recorded were identified. Most (60.2%, n = 1230) were ≥65 years, and 28.3% (n = 577) had CHF. The adjusted RSV hospitalization rate was 26.7 (95% CI: 22.2, 31.8) per 10,000 population in adults with CHF versus 3.3 (95% CI: 3.3, 3.3) per 10,000 in adults without CHF (RR: 8.1, 95% CI: 6.8, 9.7; RD: 23.4, 95% CI: 18.9, 28.5). Adults with CHF had higher rates of RSV-associated hospitalization in both age groups (<65 years and ≥65 years). Adults ≥65 y...