Roles of oral microbiota and oral-gut microbial transmission in hypertension

作者：Bo‐Yan Chen, Wen-Zhen Lin, Yulin Li, Chao Bi, Lin‐Juan Du, Yuan Liu, Lu-Jun Zhou, Ting Liu, Shuo Xu, Chaoji Shi, Hong Min Zhu, Yongli Wang, Jianyong Sun, Yan Liu, Wuchang Zhang, Haixia Lu, Yihua Wang, Qiang Feng, Fuxiang Chen, Changqian Wang, Maurizio S. Tonetti, Yaqin Zhu, Huili Zhang, Sheng‐Zhong Duan · 发表于：Journal of Advanced Research · 年份：2022 · DOI：10.1016/j.jare.2022.03.007 · 被引用次数：125 · 研究领域：Oral microbiology and periodontitis research、Gut microbiota and health、Dental Health and Care Utilization

INTRODUCTION: Considerable evidence has linked periodontitis (PD) to hypertension (HTN), but the nature behind this connection is unclear. Dysbiosis of oral microbiota leading to PD is known to aggravate different systematic diseases, but the alteration of oral microbiota in HTN and their impacts on blood pressure (BP) remains to be discovered. OBJECTIVES: To characterize the alterations of oral and gut microbiota and their roles in HTN. METHODS: We performed a cross-sectional (95 HTN participants and 39 controls) and a 6-month follow-up study (52 HTN participants and 26 controls) to analyze the roles of oral and gut microbiota in HTN. Saliva, subgingival plaques, and feces were collected for 16S rRNA gene sequencing or metagenomic analysis. C57BL/6J mice were pretreated with antibiotics to deplete gut microbiota, and then transplanted with human saliva by gavage to test the impacts of abnormal oral-gut microbial transmission on HTN. RESULTS: BP in participants with PD was higher than no PD in both cross-sectional and follow-up cohort. Relative abundances of 14 salivary genera, 15 subgingival genera and 10 gut genera significantly altered in HTN and those of 7 salivary genera, 12 subgingival genera and 6 gut genera significantly correlated with BP. Sixteen species under 5 genera were identified as oral-gut transmitters, illustrating the presence of oral-gut microbial transmission in HTN. Veillonella was a frequent oral-gut transmitter stably enriched in HTN participants of bo...