Comparative effectiveness and safety of non-vitamin K antagonists for atrial fibrillation in clinical practice: GLORIA-AF Registry

作者：Gregory Y.H. Lip, Agnieszka Kotalczyk, Christine Teutsch, Hans‐Christoph Diener, Sérgio Dubner, Jonathan L. Halperin, Changsheng Ma, Kenneth Jay Rothman, Sabrina Vogel Marler, Venkatesh Kumar Gurusamy, Menno Volkert Huisman, for the GLORIA-AF Investigators, Dzifa Wosornu Abban, Emad F. Aziz, Marica Bracic Kalan, Nasser Abdul, Luciano Marcelo Backes, Drew Bradman, Atilio Marcelo Abud, Erik Badings, Donald Brautigam, Fran Adams, Ermentina Bagni, Nicolas Breton, Srinivas Addala, Seth H. Baker, Paul J.A.M. Brouwers, Pedro Adragão, Richard Bala, Kevin F. Browne, Walter Ageno, Antonio Baldi, Jordi Bruguera Cortada, Rajesh K Aggarwal, Shigenobu Bando, Adriana Antonella Bruni, Sergio Agosti, Subhash Banerjee, Claude Brunschwig, Piergiuseppe Agostoni, Alan J. Bank, Hervé Buathier, Francisco Aznar Aguilar, Gonzalo Barón‐Esquivias, Aurélie Buhl, Julio Aguilar Linares, Craig Scott Barr, John R. Bullinga, Luis Aguinaga, Maria Bartlett, Jose Walter Cabrera, Jameel Ahmed, Vanja Bašić Kes, Alberto Caccavo, Allessandro Aiello, Giovanni Baula, Shanglang Cai, Paul David Ainsworth, Steffen Behrens, Sarah Caine, Jorge Roberto Aiub, Alan David Bell, Leonardo Calò, Raed Al-Dallow, Raffaella Benedetti, Valeria Ilia Calvi, Lisa Alderson, Juan Benezet Mazuecos, Mauricio Camarillo Sánchez, Jorge Antonio Aldrete Velasco, Bouziane Benhalima, Rui Candeias, Dimitrios K. Alexopoulos, Jutta K Bergler-Klein, Vincenzo Capuano, Fernando Alfonso Manterola, Jean-Baptiste Berneau, Alessandro Capucci, Pareed Aliyar, Richard A. Bernstein, Ronald P Caputo, David Alonso, Percy Berrospi, Tatiana Cárdenas Rizo, Fernando Augusto Alves da Costa, Sergio Berti, Francisco Cardona, José Amado, Andrea Berz, Francisco Darrieux, W. Amara, Elizabeth A. Best, Yan Carlos Duarte Vera, Mathieu Amelot, Paulo Bettencourt, Antonio Carolei, Nima Amjadi, Robert Betzu, Susana Carreño, Fabrizio Ammirati, Ravi Bhagwat, Paula Carvalho, Marianna Andrade, Luna Bhatta, Susanna Cary, Nabil S. Andrawis, Francesco M. Biscione, Gavino Casu, Giorgio Annoni, Giovanni Bisignani, Claudio Cavallini, Gerardo Ansalone, Toby Joanne Black, Guillaume Cayla, M. Kevin Ariani, Michael J. Bloch, Aldo Celentano, Juan Carlos Arias, Stephen Robert Bloom, Tae‐Joon Cha, Sebastien Arméro, Edwin Blumberg, Kwang Soo Cha, Chander Arora, Mario Bo, Jei Keon Chae, Muhammad Shakil Aslam, Ellen Bøhmer, Kathrine Chalamidas, Maarten Asselman, Andreas Bollmann, Krishnan Challappa, Philippe Audouin, Maria Grazia Bongiorni, Sunil Prakash Chand, Charles Augenbraun, Giuseppe Boriani, Harinath Chandrashekar, Şenay Aydın, D. J. Boswijk, Ludovic Chartier, Şenay Aydın, Jochen Bott, Kausik Chatterjee, Ivaneta Ayryanova, Edo Bottacchi, Carlos Antero Chavez Ayala, Aamir Cheema, Gershan K Davis, Rudolph F. Evonich, Amjad Cheema, Jean‐Marc Davy, Oksana P. Evseeva, Lin Chen, Mark Dayer, Andrey Ezhov, Shih‐Ann Chen, Marzia De Biasio, Raed N. Fahmy, Jyh-Hong Chen, Silvana De Bonis, Quan Fang, Fu‐Tien Chiang, Raffaele De Caterina, Ramin Farsad, Francesco Chiarella, Teresiano De Franceschi, Laurent Fauchier, Lin Chih-Chan, Joris R. de Groot, Stefano Favale, Yong Keun Cho, José De Horta, Maxime Fayard, Jong‐Il Choi, Axel De La Briolle, José Luis Fedele, Dong Ju Choi, Gilberto de la Peña Topete, Francesco G. Fedele, Guy Chouinard, Ângelo Amato Vicenzo de Paola, Olga Fedorishina, Danny Hoi-Fan Chow, Weimar de Souza, Steven R. Fera, Dimitrios Chrysos, A. de Veer, Luís Gustavo Gomes Ferreira, Galina A. Chumakova, Luc De Wolf, Jorge Ferreira, Eduardo Julián José Roberto Chuquiu Valenzuela, Eric Decoulx, Claudio Ferri, Nicoleta Cindea Nica, Sasalu M. Deepak, Anna Ferrier, David J. Cislowski, Pascal Defaye, Hugo Ferro, Anthony Clay, Freddy Del‐Carpio Munoz, Alexandra Vanessa Finsen, Piers Clifford, Diana Delić-Brkljačić, Brian First, Andrew S. Cohen, N. Joseph Deumite, Stuart G. Fischer, Michael N. Cohen, Silvia Di Legge, Catarina Fonseca, Serge X. Cohen, Igor Diemberger, Luísa Fonseca Almeida, Furio Colivicchi, Denise Dietz, Steven L. Forman, Rónán Collins, Pedro Dionísio, Brad Frandsen, Paolo Colonna, Qiang Dong, William J. French, Steve Compton, Fabio Rossi dos Santos, Keith A. Friedman, Derek Connolly, Elena Dotcheva, Athena Friese, Alberto Conti, Rami Doukky, Ana Gabriela Fruntelata, Gabriel Contreras Buenostro, Anthony D’Souza, Shigeru Fujii, Gregg O. Coodley, Simon William Dubrey, Stefano Fumagalli, Martin Cooper, Xavier Ducrocq, Marta Fundamenski, Julián Coronel, Dmitry Dupljakov, Yutaka Furukawa, Giovanni Corso, Mauricio Duque, Matthias Gabelmann, Juan Cosı́n-Sales, Dipankar Dutta, Nashwa Gabra, Yves Cottin, Nathalie Duvilla, Niels Gadsbøll, John Covalesky, A. Duygun, Michel Galinier, Aurel Cracan, Rainer Dziewas, Anders Gammelgaard, Filippo Crea, Charles B. Eaton, Priya Ganeshkumar, Peter Crean, William Eaves, Christopher P. Gans, JAMES F. CRENSHAW, L. A. Ebels-Tuinbeek, Antonio García Quintana, Tina Cullen, Clifford L. Ehrlich, Olivier Gartenlaub, Harald Darius, Sabine Eichinger-Hasenauer, Achille Gaspardone, Patrick Dary, Steven J. Eisenberg, Conrad Genz, Olivier Dascotte, Adnan El Jabali, Frédéric Georger, Ira M. Dauber, Mahfouz El Shahawy, Jean‐Louis Georges, Vicente Davalos, Mauro Esteves Hernandes, Steven Georgeson, Ruth E. Davies, Ana Etxeberria Izal, Evaldas Giedrimas, Mariusz Gierba, Tetsuya Haruna, Nabil F. 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Hoffer, Farzan Kamali, Víctor Manuel González López, Matthew Hoghton, Takehiro Kamo, Hervé Gorka, Kui Hong, Priit Kampus, Charles C. Gornick, Suk Keun Hong, Hisham E. Kashou, Diana Adrienne Gorog, Stevie Horbach, Andreas Kastrup, Venkat Gottipaty, Masataka Horiuchi, Apostolos G. Katsivas, Pascal Goube, Yinglong Hou, Elizabeth M. Kaufman, Ioannis A. Goudevenos, Jeff M. Hsing, Kazuya Kawai, Brett H. Graham, Chi-Hung Huang, Kenji Kawajiri, G. Stephen Greer, David S. Huckins, John F. Kazmierski, Uwe Gremmler, Kathy Hughes, P. Keeling, Paul G. Grena, A. Huizinga, José Francisco Kerr Saraiva, Martin Grond, E. L. Hulsman, Galina G. Ketova, Edoardo Gronda, Kuo‐Chun Hung, Ajit S Khaira, Gerian Grönefeld, Gyo‐Seung Hwang, А. В. Хрипун, Xiang Qun Gu, Margaret Ikpoh, Doo‐Il Kim, Ivett Guadalupe Torres Torres, Davide Imberti, Young‐Hoon Kim, Gabriele Guardigli, Hüseyin İnce, Nam Ho Kim, Carolina Guevara, Ciro Indolfi, Dae-Kyeong Kim, Alexandre Guignier, Shujiro Inoue, Jeong‐Su Kim, Michele Massimo Gulizia, Didier Irles, June Soo Kim, Michael Gumbley, Harukazu Iseki, Ki Seok Kim, Albrecht Günther, C. Noah Israel, Jin‐Bae Kim, Andrew C.T. Ha, Bruce J. Iteld, Elena Kinova, Georgios Hahalis, Venkat Ramesh Iyer, Alexander Klein, Joseph F. Hakas, Ewart Jackson-Voyzey, James J. Kmetzo, Christian Hall, Naseem Jaffrani, G. Larsen Kneller, Bing Han, Frank Jäger, Aleksandar Knežević, Seongwook Han, Martin A. James, Angela S. Koh, Joe Hargrove, Sung-Won Jang, Shunichi Koide, David R. Hargroves, Nicolás Jaramillo, Anastasios Kollias, J. A. Kooistra, Weihua Li, J. Andrew McClure, Jay C. Koons, Xiaoming Li, Terry McCormack, Martin Koschutnik, Christhoh Lichy, William C. McGarity, William J. Kostis, Ira H. Lieber, Hugh Farrell McIntyre, Dragan Kovačić, Ramon Horacio Limon Rodriguez, Brent T. McLaurin, Jacek P. Kowalczyk, Hailong Lin, Feliz Alvaro, Palomino Medina, Natalya Koziolova, Gregory Y. H. Lip, Francesco D. Melandri, Peter Kraft, Feng Liu, Hiroshi Meno, Johannes A. Kragten, Hengliang Liu, D. W. Menzies, Mori Jacob Krantz, Guillermo Llamas Esperón, Marco Antonio Mercader, Lars Krause, Nassip Llerena Navarro, Christian Meyer, Boudewijn J. Krenning, Eric Yu Wei Lo, Beat J. Meyer, F. Krikke, Sergiy Lokshyn, Jacek Miarka, Z. Kromhout, Amador López, Frank Mibach, Waldemar Krysiak, Jose Luis Lopez-Sendon, Dominik Michalski, Priya Kumar, Adalberto Menezes Lorga Filho, Patrik Michel, Thomas Kümler, Richard S. Lorraine, Rami Mihail Chreih, Malte Kuniss, Carlos Luengas, Alberto Luengas, Ghiath Mikdadi, Jen‐Yuan Kuo, Robert G. Luke, Milan Mikus, Achim Küppers, Ming Luo, Davor Miličić, Karla Marie Kurrelmeyer, Steven Lupovitch, Constantin Militaru, Choong Hwan Kwak, Philippe A. Lyrer, Sedi Minaie, Bénédicte Laboulle, Changsheng Ma, Bogdan Minescu, Arthur J. Labovitz, Genshan Ma, Iveta Mintāle, Wen Ter Lai, Irene Madariaga, Tristan Mirault, Andy Lam, Koji Maeno, Michael J. Mirro, Yat Yin Lam, Dominique Magnin, Dinesh Mistry, Fernando Lanas Zanetti, Gustavo Maid, Nicoleta Violeta Miu, Charles Landau, Sumeet K. Mainigi, Naomasa Miyamoto, Giancarlo Landini, Konstantinos P. Makaritsis, Tiziano Moccetti, Estêvão Lanna Figueiredo, Rohit Malhotra, Akber Mohammed, Torben B. Larsen, Rickey Manning, Azlisham Mohd Nor, Karine Lavandier, Athanasios J. Manolis, Michael E. Mollerus, Jessica L. LeBlanc, Helard Andrés Manrique Hurtado, Giulio Molon, Moon‐Hyoung Lee, Ioannis Mantas, Sergio Mondillo, Chang‐Hoon Lee, Fernando Manzur Jattin, Patrícia Moniz, John J. Lehman, Vicky Maqueda, Lluı́s Mont, Ana Lúcia Leitão, Niccolò Marchionni, Vicente Montagud, Nicolas Lellouche, Francisco Marin Ortuno, Oscar R. Montaña, Małgorzata Lelonek, Antonio Martín Santana, Cristina Monti, Radosław Lenarczyk, Jorge Martinez, Luciano Moretti, Timo Lenderink, Petra Maskova, Kiyoo Mori, Salvador León González, Norberto Matadamas Hernández, Andrew Moriarty, Peter Leong‐Sit, Katsuhiro Matsuda, Jacek Morka, Matthias Leschke, Tillmann Maurer, Luigi Moschini, Nicolas Ley, Ciro Mauro, Nikitas Moschos, Zhanquan Li, Erik May, Andreas Mügge, Xiaodong Li, Nolan J. Mayer, Thomas J. Mulhearn, Carmen Muresan, eena Padayattil jose, Dalton Bertolim Précoma, Michela Muriago, Francisco Gerardo Padilla Padilla, Alessandro Cesare Prelle, Wlodzimierz Jerzy Musial, Victoria Padilla Rios, John Prodafikas, Carl W. Musser, Giuseppe Pajes, Константин Викторович Протасов, Francesco Musumeci, Amritanshu Shekhar Pandey, Maurice P. Pye, Thuraia Nageh, Gaetano Paparella, Zhaohui Qiu, Hidemitsu Nakagawa, F Parı́s, Jean-Michel Quedillac, Yuichiro Nakamura, Hyung Wook Park, Dimitar H. Raev, Tôru Nakayama, Jong Sung Park, Carlos Antonio Raffo Grado, Gi‐Byoung Nam, Fragkiskos Parthenakis, Sidiqullah Rahimi, Michele Nanna, Enrico Passamonti, Arturo Raisaro, Indira Natarajan, Rajesh J. Patel, Bhola N. Rama, Hemal M. Nayak, Jaydutt Patel, Ricardo Ramos, Stefan Naydenov, Mehool Patel, Maria Ranieri, Jurica Nazlić, Janice Patrick, Nuno Miguel Ferreira Raposo, Alexandru Cristian Nechita, Ricardo Pavón Jiménez, Eric J. Rashba, Libor Nechvátal, Analía Paz, Ursula Rauch-Kroehnert, Sandra Adela Negron, Vittorio Pengo, Ramakota Reddy, James Neiman, William H. Pentz, Giulia Renda, Fernando Carvalho Neuenschwander, Beatriz Pérez, Shabbir Reza, David Neves, Alma Minerva Pérez Ríos, Luigi Ria, Anna Neykova, Alejandro Pérez-Cabezas, Dimitrios J. Richter, Ricardo Nicolás Miguel, Richard Perlman, Hans Rickli, George Nijmeh, Viktor Peršić, Werner Rieker, Alexey Nizov, Francesco Perticone, Tomas Ripolil Vera, Rodrigo Noronha Campos, Terri K. 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Steven Zukerman, Hiroki Yamanoue, Xingwei Zhang, Takeshi Yamashita · 发表于：Clinical Research in Cardiology · 年份：2022 · DOI：10.1007/s00392-022-01996-2 · 被引用次数：35 · 研究领域：Atrial Fibrillation Management and Outcomes、Vitamin K Research Studies、Venous Thromboembolism Diagnosis and Management

BACKGROUND AND PURPOSE: Prospectively collected data comparing the safety and effectiveness of individual non-vitamin K antagonists (NOACs) are lacking. Our objective was to directly compare the effectiveness and safety of NOACs in patients with newly diagnosed atrial fibrillation (AF). METHODS: In GLORIA-AF, a large, prospective, global registry program, consecutive patients with newly diagnosed AF were followed for 3 years. The comparative analyses for (1) dabigatran vs rivaroxaban or apixaban and (2) rivaroxaban vs apixaban were performed on propensity score (PS)-matched patient sets. Proportional hazards regression was used to estimate hazard ratios (HRs) for outcomes of interest. RESULTS: The GLORIA-AF Phase III registry enrolled 21,300 patients between January 2014 and December 2016. Of these, 3839 were prescribed dabigatran, 4015 rivaroxaban and 4505 apixaban, with median ages of 71.0, 71.0, and 73.0 years, respectively. In the PS-matched set, the adjusted HRs and 95% confidence intervals (CIs) for dabigatran vs rivaroxaban were, for stroke: 1.27 (0.79-2.03), major bleeding 0.59 (0.40-0.88), myocardial infarction 0.68 (0.40-1.16), and all-cause death 0.86 (0.67-1.10). For the comparison of dabigatran vs apixaban, in the PS-matched set, the adjusted HRs were, for stroke 1.16 (0.76-1.78), myocardial infarction 0.84 (0.48-1.46), major bleeding 0.98 (0.63-1.52) and all-cause death 1.01 (0.79-1.29). For the comparison of rivaroxaban vs apixaban, in the PS-matched set, the a...