A DNA‐Based Plasmonic Nanodevice for Cascade Signal Amplification

作者：Fengsong Liu, Na Li, Yingxu Shang, Yiming Wang, Qing Liu, Zhentao Ma, Qiao Jiang, Baoquan Ding · 发表于：Angewandte Chemie International Edition · 年份：2022 · DOI：10.1002/anie.202114706 · 被引用次数：49 · 研究领域：Advanced biosensing and bioanalysis techniques、Plasmonic and Surface Plasmon Research、Gold and Silver Nanoparticles Synthesis and Applications

Here, we describe a DNA circuit-aided, origami nanodevice-based plasmonic system, which performs DNA-regulated, cascade amplification of faint chemical/biological signals. In this system, two gold-nanorods (GNRs) are co-assembled onto a DNA lock-containing, tweezer-like DNA origami template. Logic circuits serve as recognition and amplification elements for specific messengers, producing DNA keys for driving conformational changes of the plasmonic nanodevices. In the presence of input signals including nucleic acids, adenosines, chiral tyrosinamides or specific receptors expressed by tumor cells, the plasmonic nanodevices can be activated to perform dynamic structural motions, reporting robust responses via plasmonic circular dichroism (CD) spectral changes. This DNA nanodevice-based system provides a different design to enrich the strategies for constructing synthetic nanomachines, enabling the customized bottom-up nanostructure construction for sensitive biological signaling.