Different Roles of Resident and Non-resident Macrophages in Cardiac Fibrosis

作者：Siyuan Hu, Meng Yang, Shumin Huang, Sen-Jie Zhong, Qian Zhang, Haichao Ding, Xiajun Xiong, Siyuan Hu, Yi Yang · 发表于：Frontiers in Cardiovascular Medicine · 年份：2022 · DOI：10.3389/fcvm.2022.818188 · 被引用次数：40 · 研究领域：Cardiac Fibrosis and Remodeling、Cardiac Structural Anomalies and Repair、Tissue Engineering and Regenerative Medicine

Cardiac fibrosis is a key pathological link of various cardiovascular diseases to heart failure. It is of great significance to deeply understand the development process of cardiac fibrosis and the cellular and molecular mechanisms involved. Macrophages play a special role in promoting heart development, maintaining myocardial cell homeostasis and heart function. They are involved in the whole process from inflammatory to cardiac fibrosis. This article summarizes the relationship between inflammation and fibrosis, discusses the bidirectional regulation of cardiac fibrosis by macrophages and analyses the functional heterogeneity of macrophages from different sources. It is believed that CCR2 – cardiac resident macrophages can promote cardiac function, but the recruitment and infiltration of CCR2 + cardiac non-resident macrophages aggravate cardiac dysfunction and heart remodeling. After heart injury, damage associated molecular patterns (DAMPs) are released in large quantities, and the inflammatory signal mediated by macrophage chemoattractant protein-1 (MCP-1) promotes the infiltration of CCR2 + monocytes and transforms into macrophages in the heart. These CCR2 + non-resident macrophages not only replace part of the CCR2 – resident macrophage subpopulation in the heart, but also cause cardiac homeostasis and hypofunction, and release a large number of mediators that promote fibroblast activation to cause cardiac fibrosis. This article reveals the cell biology mechanism of res...