PSMA-targeting TGFβ-insensitive armored CAR T cells in metastatic castration-resistant prostate cancer: a phase 1 trial

作者：Vivek Narayan, Julie S. Barber-Rotenberg, In-Young Jung, Simon F. Lacey, Andrew J. Rech, Megan M. Davis, Wei‐Ting Hwang, Priti Lal, Erica L. Carpenter, Shannon L. Maude, Gabriela Plesa, Neha Vapiwala, Anne Chew, Michael Moniak, Ronnie Sebro, Michael D. Farwell, Amy Marshall, Joan Gilmore, Lester Lledo, Karen Dengel, S. Church, Tyler Hether, Jun Xu, Mercy Gohil, Thomas H. Buckingham, Stephanie S. Yee, Vanessa Gonzalez, Irina Kulikovskaya, Fang Chen, Lifeng Tian, Kyle Tien, Whitney L. Gladney, Christopher L. Nobles, Hayley E. Raymond, Prostate Cancer Cellular Therapy Program Investigators, Diane Frazee, Mary Truran, Elizabeth Veloso, Holly McConville, Jonathan Aguedelo, Samantha Hower, Sophia Ngo, Julie K. Jadlowsky, J. Joseph Melenhorst, Aoife M. Roche, J.K. Everett, Minnal Gupta, Farzana Nazimuddin, Chelsie Bartoszek, Natalka Koterba, Rachael Reynolds, Farris Ellington, Christopher C. Kloss, Ji‐Hyun Lee, Yangbing Zhao, John Scholler, James L. Riley, Christina Bailey, Andrew J. P. White, Briana M. Hudson, Pearl Chang, Marcela V. Maus, Bruce L. Levine, Elizabeth O. Hexner, Donald L. Siegel, Frederic D. Bushman, Carl H. June, Joseph A. Fraietta, Naomi B. Haas · 发表于：Nature Medicine · 年份：2022 · DOI：10.1038/s41591-022-01726-1 · 被引用次数：525 · 研究领域：CAR-T cell therapy research、Virus-based gene therapy research、Immunotherapy and Immune Responses