Burden of whooping cough in China (PertussisChina): study protocol of a prospective, population-based case–control study

作者：Jianxing Yu, Hanqing He, Yanyang Zhang, Yuan Gao, Chuanwei Chen, Juan Xu, Li Xu, Xiaoxiao Zhang, Qianqian Zhou, Yao Zhu, Xuewen Tang, Guo Y, Zhiping Chen, Zhujun Shao · 发表于：BMJ Open · 年份：2022 · DOI：10.1136/bmjopen-2021-053316 · 被引用次数：15 · 研究领域：Bacterial Infections and Vaccines、Pneumonia and Respiratory Infections、Vaccine Coverage and Hesitancy

Introduction Pertussis is one of the top 10 diseases of children under 10 years of age, and the few vaccine-preventable diseases who is on a rise in China in recent years; however, the true burden of pertussis, including age-stratified incidence and risk factors of severe sequelae, are under-recognised. We aim to estimate the health burden of laboratory-confirmed pertussis by age groups, considering the setting of illness onset (ie, in community, outpatient and inpatient), in a Chinese population (~2.23 million in total) at two sites. Methods and analysis This paper describes the study design of a 1-year, prospective, age-stratified and population-based case–control study, including site selection, study population, case registry, ascertainment and enrolment, control recruitment, follow-up of case, microbiological methods, data collection, quality control activities and statistical methods used to generate incidence estimates. During June 2021 through May 2022, registry of suspected pertussis cases (namely chronic/persistent cough) will be conducted in several participating hospitals (SHs) at the two sites, which are selected based on Healthcare Utilisation and Attitudes Surveys (HUAS) carried out before study initiation. A case–control study will be conducted in the SHs and we aim to enrol a total of 1000 suspected pertussis cases (ie, all hospital admissions and the first 1–3 outpatient visits each week each hospital) and 2000 frequency matched healthy controls in community...