Association of Habitual Alcohol Intake With Risk of Cardiovascular Disease

作者：Kiran J. Biddinger, Connor A. Emdin, Mary E. Haas, Minxian Wang, George Hindy, Patrick T. Ellinor, Sekar Kathiresan, Amit V. Khera, Krishna G. Aragam · 发表于：JAMA Network Open · 年份：2022 · DOI：10.1001/jamanetworkopen.2022.3849 · 被引用次数：461 · 研究领域：Alcohol Consumption and Health Effects、Substance Abuse Treatment and Outcomes、Genetic Associations and Epidemiology

Importance: Observational studies have consistently proposed cardiovascular benefits associated with light alcohol consumption, while recent genetic analyses (ie, mendelian randomization studies) have suggested a possible causal link between alcohol intake and increased risk of cardiovascular disease. However, traditional approaches to genetic epidemiology assume a linear association and thus have not fully evaluated dose-response estimates of risk across different levels of alcohol intake. Objectives: To assess the association of habitual alcohol intake with cardiovascular disease risk and to evaluate the direction and relative magnitude of cardiovascular risk associated with different amounts of alcohol consumption. Design, Setting, and Participants: This cohort study used the UK Biobank (2006-2010, follow-up until 2016) to examine confounding in epidemiologic associations between alcohol intake and cardiovascular diseases. Using both traditional (ie, linear) and nonlinear mendelian randomization, potential associations between alcohol consumption and cardiovascular diseases (eg, hypertension and coronary artery disease) as well as corresponding association shapes were assessed. Data analysis was conducted from July 2019 to January 2022. Exposures: Genetic predisposition to alcohol intake. Main Outcomes and Measures: The association between alcohol consumption and cardiovascular diseases, including hypertension, coronary artery disease, myocardial infarction, stroke, heart ...