Altered Brain Structural Reorganization and Hierarchical Integrated Processing in Obesity

作者：Peng Zhang, Guowei Wu, Lirong Tang, Fengxia Yu, Meng‐yi Li, Zheng Wang, Zheng Wang, Zhenghan Yang, Zhongtao Zhang, Han Lv, Yang Liu, Zhen-chang Wang, Zhen-chang Wang · 发表于：Frontiers in Neuroscience · 年份：2022 · DOI：10.3389/fnins.2022.796792 · 被引用次数：9 · 研究领域：Eating Disorders and Behaviors、Regulation of Appetite and Obesity、Diet and metabolism studies

The brain receives sensory information about food, evaluates its desirability and value, and responds with approach or withdrawal. The evaluation process of food in the brain with obesity may involve a variety of neurocircuit abnormalities in the integration of internal and external information processing. There is a lack of consistency of the results extant reported for aberrant changes in the brain with obesity that prohibits key brain alterations to be identified. Moreover, most studies focus on the observation of neural plasticity of function or structure, and the evidence for functional and structural correlations in the neuronal plasticity process of obesity is still insufficient. The aims of this article are to explore the key neural structural regions and the hierarchical activity pattern of key structural nodes and evaluate the correlation between changes in functional modulation and eating behavior. Forty-two participants with obesity and 33 normal-weight volunteers were recruited. Gray matter volume (GMV) and Granger causality analysis (GCA) were performed using the DPARSF, CAT12, and DynamicBC toolbox. Compared with the normal weight group, the obesity group exhibited significantly increased GMV in the left parahippocampal gyrus (PG). The obesity group showed decreased causal inflow to the left PG from the left orbitofrontal cortex (OFC), right calcarine, and bilateral supplementary motor area (SMA). Decreased causal outflow to the left OFC, right precuneus, and r...