The rationale and potential for using Lactobacillus in the management of periodontitis

作者：Jiaqi Wang, Yingman Liu, Weiru Wang, Jiaojiao Ma, Manman Zhang, Xiaoying Lü, Jie Liu, Yurong Kou · 发表于：The Journal of Microbiology · 年份：2022 · DOI：10.1007/s12275-022-1514-4 · 被引用次数：23 · 研究领域：Oral microbiology and periodontitis research、Probiotics and Fermented Foods、Salivary Gland Disorders and Functions

Periodontitis refers to a wide range of the inflammatory conditions of supporting dental structures. For some patients with periodontitis, antibacterial agents are needed as an adjuvant to mechanical debridement treatments and oral hygiene maintenance. However, the widespread use of broad-spectrum antibiotics for the prophylaxis and treatment of periodontal infections results in the emergence of resistant pathogens. Therefore, probiotics have become markedly interesting to researchers as a potentially safe alternative to periodontal treatment and maintenance. Probiotics have been used in medicine for decades and extensively applied to the treatment of inflammatory diseases through the modulation of microbial synergy and other mechanisms. A growing amount of evidence has shown that using Lactobacillus strains for oral cavity maintenance could improve periodontal health. In this study, we reviewed studies showing proof of the inhibitory effects of Lactobacillus species on periodontal inflammation. We also explored the rationale and potential for using Lactobacillus species in the management of periodontitis.