Cerebral Blood Flow Pattern Changes in Unilateral Sudden Sensorineural Hearing Loss

作者：Yue Chen, Haimei Li, Bing Liu, Wenwen Gao, Aocai Yang, Kuan Lv, Hui Xia, Wenwei Zhang, Hongwei Yu, Jian Liu, Xiuxiu Liu, Yige Wang, Honglei Han, Guolin Ma · 发表于：Frontiers in Neuroscience · 年份：2022 · DOI：10.3389/fnins.2022.856710 · 被引用次数：13 · 研究领域：Vestibular and auditory disorders、Hearing, Cochlea, Tinnitus, Genetics、Hearing Loss and Rehabilitation

Objective This study analyzed the differences in the cerebral blood flow (CBF) between unilateral Sudden Sensorineural Hearing Loss (SSNHL) patients and healthy controls (HCs). We also investigated CBF differences in auditory-related areas in patients with left- and right-sided SSNHL (lSSNHL and rSSNHL) and HCs. We further explore the correlation between unilateral SSNHL characteristics and changes in the CBF. Methods 36 patients with unilateral SSNHL (15 males and 21 females, 40.39 ± 13.42 years) and 36 HCs (15 males and 21 females, 40.39 ± 14.11 years) were recruited. CBF images were collected and analyzed using arterial spin labeling (ASL). CereFlow software was used for the post-processing of the ASL data to obtain the CBF value of 246 subregions within brainnetome atlas (BNA). The Two-sample t -test was used to compare CBF differences between SSNHL patients and HCs. One-way ANOVA or Kruskal-Wallis test was used to compare the CBF difference of auditory-related areas among the three groups (lSSNHL, rSSNHL, and HCs). Then, the correlation between CBF changes and specific clinical characteristics were calculated. Results The SSNHL patients exhibited decreased CBF in the bilateral middle frontal gyrus (MFG, MFG_7_1 and MFG_7_3), the contralateral precentral gyrus (PrG, PrG_6_3) and the bilateral superior parietal lobule (SPL, bilateral SPL_5_1, SPL_5_2, and ipsilateral SPL_5_4), p < 0.0002. Compared with HCs, unilateral SSNHL patients exhibited increased rCBF in the b...