Tuberculosis Treatment Monitoring and Outcome Measures: New Interest and New Strategies

作者：Jan Heyckendorf, Sophia B. Georghiou, Nicole Frahm, Norbert Heinrich, Irina Kontsevaya, Maja Reimann, David M. Holtzman, Marjorie Z. Imperial, Daniela María Cirillo, Stephen H. Gillespie, Morten Rühwald · 发表于：Clinical Microbiology Reviews · 年份：2022 · DOI：10.1128/cmr.00227-21 · 被引用次数：82 · 研究领域：Tuberculosis Research and Epidemiology、Infectious Diseases and Tuberculosis、Mycobacterium research and diagnosis

Despite the advent of new diagnostics, drugs and regimens, tuberculosis (TB) remains a global public health threat. A significant challenge for TB control efforts has been the monitoring of TB therapy and determination of TB treatment success. Current recommendations for TB treatment monitoring rely on sputum and culture conversion, which have low sensitivity and long turnaround times, present biohazard risk, and are prone to contamination, undermining their usefulness as clinical treatment monitoring tools and for drug development. We review the pipeline of molecular technologies and assays that serve as suitable substitutes for current culture-based readouts for treatment response and outcome with the potential to change TB therapy monitoring and accelerate drug development.