Enantioselective Pictet–Spengler Condensation to Access the Total Synthesis of (+)‐Tabertinggine

作者：Dan Long, Gaoyuan Zhao, Zhiqiang Liu, Peiqi Chen, Shiqiang Ma, Xingang Xie, X. She · 发表于：European Journal of Organic Chemistry · 年份：2022 · DOI：10.1002/ejoc.202200088 · 被引用次数：22 · 研究领域：Alkaloids: synthesis and pharmacology、Chemical synthesis and alkaloids、Traditional and Medicinal Uses of Annonaceae

Abstract A chiral phosphoric acid (CPA)‐catalyzed enantioselective Pictet–Spengler condensation/lactamization cascade reaction was established, which paved the way of the collective synthesis of iboga‐type indole alkaloids. Herein, we presented the asymmetric total synthesis of iboga‐type indole alkaloid (+)‐tabertinggine.